Lynch syndrome (HNPCC) and microsatellite instability analysis guidelines
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چکیده
منابع مشابه
Lynch syndrome (HNPCC) and microsatellite instability analysis guidelines.
The “International Workshop on Diagnostic Guidelines for Hereditary Non-Polyposis Colorectal Cancer and Microsatellite Instability” represents the third workshop in this series. In November 1996, NCI’s DCP convened a workshop entitled “Intersection of Pathology and Genetics in HNPCC Syndrome.” In December 1997, another workshop, “International Workshop on Microsatellite Instability and Replicat...
متن کاملLynch Syndrome (HNPCC) and Microsatellite Instability
A departure from the concept of simple adenoma to carcinoma sequence is the realization that colorectal cancer (CRC) develops through at least two major molecular pathogenic pathways, namely chromosomal instability (CIN) and microsatellite instability (MSI) [1,2]. The mechanisms underlying CIN might have been the first to be deciphered but they are just being understood in detail. It is propose...
متن کاملLynch syndrome (HNPCC)
Lynch syndrome, also referred to as hereditary non-polyposis colorectal cancer (HNPCC), accounts for somewhere between 2 and 5% of all CRC. It has been shown that Lynch syndrome (LS) is a result of germline mutations in genes involved in DNA mismatch repair (MMR) MSH2, MLH1, MSH6, and PMS2, whereas as HNPCC refers to families that adhere to the Amsterdam criteria or iterations of it. More recen...
متن کاملRevised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability.
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, neoplastic lesions, and microsatellite instability (MSI). Because cancers with MSI account for approximately 15% of all colorectal cancers and because of the need for a better understanding of the clinical and histologic manifestations of ...
متن کاملCOMMENTARY Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability
Asad Umar, C. Richard Boland, Jonathan P. Terdiman, Sapna Syngal, Albert de la Chapelle, Josef Rüschoff, Richard Fishel, Noralane M. Lindor, Lawrence J. Burgart, Richard Hamelin, Stanley R. Hamilton, Robert A. Hiatt, Jeremy Jass, Annika Lindblom, Henry T. Lynch, Paı̈vi Peltomaki, Scott D. Ramsey, Miguel A. Rodriguez-Bigas, Hans F. A. Vasen, Ernest T. Hawk, J. Carl Barrett, Andrew N. Freedman, Su...
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ژورنال
عنوان ژورنال: Cancer Biomarkers
سال: 2006
ISSN: 1875-8592,1574-0153
DOI: 10.3233/cbm-2006-21-201